MOLECULAR MECHANISMS
Cellular fusion is a significant driver of cardiomyocyte polyploidization.
Congenital heart disease is the most common birth defect and is often associated with heart failure. Conventional heart failure medications are not effective in these patients. Regenerative strategies have the potential for improving this situation. Our recent finding indicates that polyploidization creates a mechanistic barrier to heart regeneration. Our lab is working on deciphering the mechanism of the generation of polyploid cardiomyocytes. By utilising non-inherited somatic mutations record as a “endogenous barcode” and, we are studying the clonal structure of polyploid cardiomyocytes regeneration.
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View abstract