[et_pb_section fb_built=”1″ _builder_version=”4.16″ custom_padding=”0|0px|0|0|false|false” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ custom_padding=”30px|0px|25px|0px|false|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text admin_label=”Page Title” _builder_version=”4.16″ global_colors_info=”{}”]<\/p>\n
MOLECULAR MECHANISMS<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ background_color=”#efefef” custom_margin=”0px||||false|false” custom_padding=”20px|0px|20px|0px|false|false” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ custom_padding=”30px||1px|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text admin_label=”Research Section Title” module_id=”neuromodulation” _builder_version=”4.16″ custom_margin=”0px||15px||false|false” custom_padding=”0px||0px||false|false” global_colors_info=”{}”]<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”3_5,2_5″ _builder_version=”4.16″ min_height=”372.3px” custom_margin=”0px||||false|false” custom_padding=”0px||||false|false” global_colors_info=”{}”][et_pb_column type=”3_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/bchgenetics.org\/ChoudhuryLab\/wp-content\/uploads\/2021\/05\/research-molecular-mechanism.jpg” alt=”axon regeneration and function recovery after CNS injury” title_text=”research-molecular-mechanism” src_last_edited=”off|desktop” _builder_version=”4.16″ _module_preset=”default” width_tablet=”” width_phone=”” width_last_edited=”on|desktop” min_height_tablet=”” min_height_phone=”” min_height_last_edited=”on|phone” custom_margin=”0px||15px||false|false” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font_size=”17px” custom_margin=”0px||||false|false” custom_padding=”0px||||false|false” global_colors_info=”{}”]<\/p>\n
Congenital heart disease is the most common birth defect and is often associated with heart failure. Conventional heart failure medications are not effective in these patients. Regenerative strategies have the potential for improving this situation. Our recent finding indicates that polyploidization creates a mechanistic barrier to heart regeneration. Our lab is working on deciphering the mechanism of the generation of polyploid cardiomyocytes. By utilising non-inherited somatic mutations record as a \u201cendogenous barcode\u201d and, we are studying the clonal structure of polyploid cardiomyocytes regeneration.<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ _module_preset=”default” custom_padding=”||40px|||” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text admin_label=”Scroll Arrow” _builder_version=”4.16″ _module_preset=”default” text_text_color=”#000000″ text_font_size=”24px” background_enable_color=”off” custom_margin=”0px||0px||false|false” custom_padding=”0px||0px||true|false” global_colors_info=”{}” text_font_size__hover_enabled=”on|hover” text_font_size__hover=”36px”]<\/p>\n
\u2193<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ background_color=”#efefef” custom_margin=”50px||||false|false” custom_padding=”20px|0px|20px|0px|false|false” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ custom_padding=”30px||1px|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text admin_label=”Research Section Title” module_id=”neuromodulation” _builder_version=”4.16″ custom_margin=”0px||15px||false|false” custom_padding=”0px||0px||false|false” global_colors_info=”{}”]<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ custom_margin=”||30px||false|false” custom_padding=”||||false|false” border_width_bottom=”1px” border_color_bottom=”#007da0″ locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ _module_preset=”default” custom_margin=”0px||||false|false” global_colors_info=”{}”]<\/p>\n
Lamin B2 Levels Regulate Polyploidization of Cardiomyocyte Nuclei and Myocardial Regeneration.<\/strong> [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ custom_margin=”||30px||false|false” custom_padding=”||||false|false” border_width_bottom=”1px” border_color_bottom=”#007da0″ locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ _module_preset=”default” custom_margin=”0px||||false|false” global_colors_info=”{}”]<\/p>\n Control of cytokinesis by \u03b2-adrenergic receptors indicates an approach for regulating cardiomyocyte endowment.<\/strong> Neuregulin stimulation of cardiomyocyte regeneration in mice and human myocardium reveals a therapeutic window.<\/strong> <\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ module_class=”neuromodulation” _builder_version=”4.16″ background_enable_color=”off” custom_margin=”100px||0px||false|false” custom_padding=”0px||0px||false|false” global_colors_info=”{}”][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" MOLECULAR MECHANISMSCellular fusion is a significant driver of cardiomyocyte polyploidization.Congenital heart disease is the most common birth defect and is often associated with heart failure. Conventional heart failure medications are not effective in these patients. Regenerative strategies have the potential for improving this situation. Our recent finding indicates that polyploidization creates a mechanistic barrier to […]<\/p>\n","protected":false},"author":12,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-6386","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/bchgenetics.org\/ChoudhuryLab\/wp-json\/wp\/v2\/pages\/6386","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bchgenetics.org\/ChoudhuryLab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/bchgenetics.org\/ChoudhuryLab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/bchgenetics.org\/ChoudhuryLab\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/bchgenetics.org\/ChoudhuryLab\/wp-json\/wp\/v2\/comments?post=6386"}],"version-history":[{"count":5,"href":"https:\/\/bchgenetics.org\/ChoudhuryLab\/wp-json\/wp\/v2\/pages\/6386\/revisions"}],"predecessor-version":[{"id":6961,"href":"https:\/\/bchgenetics.org\/ChoudhuryLab\/wp-json\/wp\/v2\/pages\/6386\/revisions\/6961"}],"wp:attachment":[{"href":"https:\/\/bchgenetics.org\/ChoudhuryLab\/wp-json\/wp\/v2\/media?parent=6386"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Dev Cell. 2020 04 06; 53(1):42-59.e11.\u00a0<\/span>View abstract<\/a><\/p>\n<\/i><\/span><\/h2>\n
\nLiu H, Zhang CH, Ammanamanchi N, Suresh S, Lewarchik C, Rao K, Uys GM, Han L, Abrial M, Yimlamai D, Ganapathy B, Guillermier C, Chen N, Khaladkar M, Spaethling J, Eberwine JH, Kim J, Walsh S, Choudhury S, Little K, Francis K, Sharma M, Viegas M, Bais A, Kostka D, Ding J, Bar-Joseph Z, Wu Y, Yechoor V, Moulik M, Johnson J, Weinberg J, Reyes-M\u00fagica M, Steinhauser ML, K\u00fchn B. Sci Transl Med. 2019 Oct 9;11(513):eaaw6419. doi: 10.1126\/scitranslmed.aaw6419. PMID: 31597755\u00a0<\/span>View abstract<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ custom_margin=”||30px||false|false” custom_padding=”||||false|false” border_width_bottom=”1px” border_color_bottom=”#007da0″ locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ _module_preset=”default” custom_margin=”0px||||false|false” global_colors_info=”{}”]<\/p>\n<\/i><\/span><\/h2>\n
Brian D Polizzotti, Balakrishnan Ganapathy, Stuart Walsh, Sangita Choudhury, Niyatie Ammanamanchi, David G Bennett, Cristobal G dos Remedios, Bernhard J Haubner, Josef M Penninger, Bernhard K\u00fchn.
Sci Transl Med<\/em>. 2015 Apr 1;7(281):281ra45. doi: 10.1126\/scitranslmed.aaa5171.
<\/span>View abstract<\/a><\/p>\n